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ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality
PtdIns(3,5)P(2) is vital in differentiation and development of multicellular organisms because the knockout of the PtdIns(3,5)P(2)-synthesizing enzyme PIKfyve or its associated regulator, ArPIKfyve, is lethal. In previous work with endogenous proteins we identified that Sac3, a phosphatase that turn...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756758/ https://ncbi.nlm.nih.gov/pubmed/18950639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.10.009 |
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