The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development: PREIMPLANTATION LETHALITY OF PIKfyve(−/−) EMBRYOS BUT NORMALITY OF PIKfyve(+/−) MICE

Gene mutations in the phosphoinositide-metabolizing enzymes are linked to various human diseases. In mammals, PIKfyve synthesizes PtdIns(3,5)P(2) and PtdIns5P lipids that regulate endosomal trafficking and responses to extracellular stimuli. The consequence of pikfyve gene ablation in mammals is unk...

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Detalhes bibliográficos
Main Authors: Ikonomov, Ognian C., Sbrissa, Diego, Delvecchio, Khortnal, Xie, Yufen, Jin, Jian-Ping, Rappolee, Daniel, Shisheva, Assia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075686/
https://ncbi.nlm.nih.gov/pubmed/21349843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.222364
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