Unexpected severe consequences of Pikfyve deletion by aP2‐ or Aq‐promoter‐driven Cre expression for glucose homeostasis and mammary gland development

Systemic deficiency of PIKfyve, the evolutionarily conserved phosphoinositide kinase synthesizing cellular PtdIns5P and PtdIns(3,5)P(2) and implicated in insulin signaling, causes early embryonic death in mice. In contrast, mice with muscle‐specific Pikfyve disruption have normal lifespan but exhibi...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Ikonomov, Ognian C., Sbrissa, Diego, Delvecchio, Khortnal, A. Rillema, James, Shisheva, Assia
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908490/
https://ncbi.nlm.nih.gov/pubmed/27273882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12812
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