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A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

Werner syndrome (WS) is a premature aging disorder where the affected individuals appear much older than their chronological age. The single gene that is defective in WS encodes a protein (WRN) that has ATPase, helicase and 3′→5′ exonuclease activities. Our laboratory has recently uncovered a physic...

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Hlavní autoři: Orren, David K., Machwe, Amrita, Karmakar, Parimal, Piotrowski, Jason, Cooper, Marcus P., Bohr, Vilhelm A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2001
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC37248/
https://ncbi.nlm.nih.gov/pubmed/11328876
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