Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells

Reduced autophagy may be associated with normal and pathological aging. Here we report a link between autophagy and Werner protein (WRNp), mutated in Werner syndrome, the human premature aging Werner syndrome (WS). WRN mutant fibroblast AG11395 and AG05229 respond weakly to starvation induced autoph...

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Bibliographic Details
Published in:Biochim Biophys Acta
Main Authors: Maity, Jyotirindra, Bohr, Vilhelm A., Laskar, Aparna, Karmakar, Parimal
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582615/
https://ncbi.nlm.nih.gov/pubmed/25257404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.09.007
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