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Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins

Impaired autophagy may be associated with normal and pathological aging. Here we explore a link between autophagy and domain function of Werner protein (WRNp). Werner (WRN) mutant cell lines AG11395, AG05229 and normal aged fibroblast AG13129 display a deficient response to tunicamycin mediated endo...

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Detalhes bibliográficos
Publicado no:DNA Repair (Amst)
Main Authors: Maity, Jyotirindra, Das, Biswadip, Bohr, Vilhelm A., Karmakar, Parimal
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338341/
https://ncbi.nlm.nih.gov/pubmed/29800817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.05.003
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