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Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins
Impaired autophagy may be associated with normal and pathological aging. Here we explore a link between autophagy and domain function of Werner protein (WRNp). Werner (WRN) mutant cell lines AG11395, AG05229 and normal aged fibroblast AG13129 display a deficient response to tunicamycin mediated endo...
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| Publicado en: | DNA Repair (Amst) |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6338341/ https://ncbi.nlm.nih.gov/pubmed/29800817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.05.003 |
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