DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities

Werner protein (WRN), member of the RecQ helicase family, is a helicase and exonuclease, and participates in multiple DNA metabolic processes including DNA replication, recombination and DNA repair. Mutations in the WRN gene cause Werner syndrome, associated with premature aging, genome instability...

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Bibliographic Details
Main Authors: Tadokoro, Takashi, Kulikowicz, Tomasz, Dawut, Lale, Croteau, Deborah L., Bohr, Vilhelm A.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2012
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409678/
https://ncbi.nlm.nih.gov/pubmed/22713343
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