A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

Werner syndrome (WS) is a premature aging disorder where the affected individuals appear much older than their chronological age. The single gene that is defective in WS encodes a protein (WRN) that has ATPase, helicase and 3′→5′ exonuclease activities. Our laboratory has recently uncovered a physic...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Orren, David K., Machwe, Amrita, Karmakar, Parimal, Piotrowski, Jason, Cooper, Marcus P., Bohr, Vilhelm A.
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 2001
Sujets:	Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37248/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11328876/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.9.1926
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