N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits

N-truncated Aβ(4-42) is highly abundant in Alzheimer disease (AD) brain and was the first Aβ peptide discovered in AD plaques. However, a possible role in AD aetiology has largely been neglected. In the present report, we demonstrate that Aβ(4-42) rapidly forms aggregates possessing a high aggregati...

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Autors principals: Bouter, Yvonne, Dietrich, Katharina, Wittnam, Jessica L., Rezaei-Ghaleh, Nasrollah, Pillot, Thierry, Papot-Couturier, Sophie, Lefebvre, Thomas, Sprenger, Frederick, Wirths, Oliver, Zweckstetter, Markus, Bayer, Thomas A.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2013
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3722453/
https://ncbi.nlm.nih.gov/pubmed/23685882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1129-2
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