Tumor-Associated Mutations in O(6)-Methylguanine DNA-Methyltransferase (MGMT) Reduce DNA Repair Functionality

MGMT is the primary vehicle for cellular removal of alkyl lesions from the O-6 position of guanine and the O-4 position of thymine. While key to the maintenance of genomic integrity, MGMT also removes damage induced by alkylating chemotherapies, inhibiting the efficacy of cancer treatment. Germline...

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Detalhes bibliográficos
Main Authors: Lamb, Kristy L., Liu, Yanfeng, Ishiguro, Kimiko, Kwon, Youngho, Paquet, Nicolas, Sartorelli, Alan C., Sung, Patrick, Rockwell, Sara, Sweasy, Joann B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720794/
https://ncbi.nlm.nih.gov/pubmed/23065697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.21964
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