O(6)‐Methylguanine‐DNA Methyltransferase (MGMT) as a Determinant of Resistance to Camptothecin Derivatives

The precise mechanisms of resistance to camptothecin (CPT)‐derived DNA topoisomerase (topo I) inhibitors and the determinants remain unclear. We found that a DNA repair protein, O(6)‐methylguanine‐DNA methyltransferase(MGMT), participated in resistance to irinotecan hydrochloride (CPT‐11), its activ...

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Publicat a:Jpn J Cancer Res
Autors principals: Okamoto, Ryo, Takano, Hiroshi, Okamura, Tatsunori, Park, Ji‐Seon, Tanimoto, Keiji, Sekikawa, Takashi, Yamamoto, Wataru, Sparreboom, Alex, Verweij, Jaap, Nishiyama, Masahiko
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2002
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926864/
https://ncbi.nlm.nih.gov/pubmed/11802813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2002.tb01205.x
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