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O(6)‐Methylguanine‐DNA Methyltransferase (MGMT) as a Determinant of Resistance to Camptothecin Derivatives
The precise mechanisms of resistance to camptothecin (CPT)‐derived DNA topoisomerase (topo I) inhibitors and the determinants remain unclear. We found that a DNA repair protein, O(6)‐methylguanine‐DNA methyltransferase(MGMT), participated in resistance to irinotecan hydrochloride (CPT‐11), its activ...
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| Опубликовано в: : | Jpn J Cancer Res |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Blackwell Publishing Ltd
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5926864/ https://ncbi.nlm.nih.gov/pubmed/11802813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2002.tb01205.x |
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