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O(6)-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy

Chemoresistance has been a significant problem affecting the efficacy of drugs targeting tumors for decades. MGMT, known as O(6)-methylguanine-DNA methyltransferase, is a DNA repair enzyme that plays an important role in chemoresistance to alkylating agents. Hence, MGMT is considered a promising tar...

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Bibliografiske detaljer
Udgivet i:Front Oncol
Main Authors: Yu, Wei, Zhang, Lili, Wei, Qichun, Shao, Anwen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6979006/
https://ncbi.nlm.nih.gov/pubmed/32010632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01547
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