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Tumor-Associated Mutations in O(6)-Methylguanine DNA-Methyltransferase (MGMT) Reduce DNA Repair Functionality
MGMT is the primary vehicle for cellular removal of alkyl lesions from the O-6 position of guanine and the O-4 position of thymine. While key to the maintenance of genomic integrity, MGMT also removes damage induced by alkylating chemotherapies, inhibiting the efficacy of cancer treatment. Germline...
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| Autores principales: | , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3720794/ https://ncbi.nlm.nih.gov/pubmed/23065697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.21964 |
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