53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions

The DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1, and thereby favors repair by non-homologous end joining (NHEJ) as opposed to homologous recombination (HR). During S phase, BRCA1 antagonizes 53BP1 to promote HR. The pro-NHEJ and anti-recombinase functions...

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Main Authors: Callen, Elsa, Di Virgilio, Michela, Kruhlak, Michael J., Nieto-Soler, Maria, Wong, Nancy, Chen, Hua-Tang, Faryabi, Robert B., Polato, Federica, Santos, Margarida, Starnes, Linda M., Wesemann, Duane R., Lee, Ji-Eun, Tubbs, Anthony, Sleckman, Barry P., Daniel, Jeremy A., Ge, Kai, Alt, Frederick W., Fernandez-Capetillo, Oscar, Nussenzweig, Michel C., Nussenzweig, André
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713552/
https://ncbi.nlm.nih.gov/pubmed/23727112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.05.023
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