Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

We measured the mRNA and protein expression of the key gluconeogenic enzymes in human liver biopsy specimens and found that only hepatic pyruvate carboxylase protein levels related strongly with glycemia. We assessed the role of pyruvate carboxylase in regulating glucose and lipid metabolism in rats...

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Main Authors: Kumashiro, Naoki, Beddow, Sara A., Vatner, Daniel F., Majumdar, Sachin K., Cantley, Jennifer L., Guebre-Egziabher, Fitsum, Fat, Ioana, Guigni, Blas, Jurczak, Michael J., Birkenfeld, Andreas L., Kahn, Mario, Perler, Bryce K., Puchowicz, Michelle A., Manchem, Vara Prasad, Bhanot, Sanjay, Still, Christopher D., Gerhard, Glenn S., Petersen, Kitt Falk, Cline, Gary W., Shulman, Gerald I., Samuel, Varman T.
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2013
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712050/
https://ncbi.nlm.nih.gov/pubmed/23423574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1311
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