Protein Targets of Thioacetamide Metabolites in Rat Hepatocytes

Thioacetamide (TA) has long been known as a hepatotoxicant whose bioactivation requires S-oxidation to thioacetamide S-oxide (TASO) and then to the very reactive S,S-dioxide (TASO(2)). The latter can tautomerize to form acylating species capable of covalently modifying cellular nucleophiles includin...

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Bibliografiske detaljer
Main Authors: Koen, Yakov M., Sarma, Diganta, Hajovsky, Heather, Galeva, Nadezhda A., Williams, Todd D., Staudinger, Jeffrey L., Hanzlik, Robert P.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710294/
https://ncbi.nlm.nih.gov/pubmed/23465048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400001x
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