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Metabolism and Toxicity of Thioacetamide and Thioacetamide S-Oxide in Rat Hepatocytes
The hepatotoxicity of thioacetamide (TA) has been known since 1948. In rats, single doses cause centrilobular necrosis accompanied by increases in plasma transaminases and bilirubin. To elicit these effects TA requires oxidative bioactivation leading first to its S-oxide (TASO) and then to its chemi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3444651/ https://ncbi.nlm.nih.gov/pubmed/22867114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx3002719 |
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