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Protein Targets of Thioacetamide Metabolites in Rat Hepatocytes
Thioacetamide (TA) has long been known as a hepatotoxicant whose bioactivation requires S-oxidation to thioacetamide S-oxide (TASO) and then to the very reactive S,S-dioxide (TASO(2)). The latter can tautomerize to form acylating species capable of covalently modifying cellular nucleophiles includin...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3710294/ https://ncbi.nlm.nih.gov/pubmed/23465048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400001x |
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