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Identification of Protein Targets of Reactive Metabolites of Tienilic Acid in Human Hepatocytes

Tienilic acid (TA) is a uricosuric diuretic that was withdrawn from the market only months after its introduction because of reports of serious incidents of drug-induced liver injury including some fatalities. Its hepatotoxicity is considered to be primarily immunoallergic in nature. Like other thio...

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Detalhes bibliográficos
Main Authors: Koen, Yakov M., Sarma, Diganta, Williams, Todd D., Galeva, Nadezhda A., Obach, R. Scott, Hanzlik, Robert P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358484/
https://ncbi.nlm.nih.gov/pubmed/22462724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300103j
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