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Identification of Protein Targets of Reactive Metabolites of Tienilic Acid in Human Hepatocytes
Tienilic acid (TA) is a uricosuric diuretic that was withdrawn from the market only months after its introduction because of reports of serious incidents of drug-induced liver injury including some fatalities. Its hepatotoxicity is considered to be primarily immunoallergic in nature. Like other thio...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358484/ https://ncbi.nlm.nih.gov/pubmed/22462724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300103j |
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