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Protein Targets of Reactive Metabolites of Thiobenzamide in Rat Liver In Vivo
Thiobenzamide (TB) is a potent hepatotoxin in rats, causing dose-dependent hyperbilirubinemia, steatosis, and centrolobular necrosis. These effects arise subsequent to and appear to result from the covalent binding of the iminosulfinic acid metabolite of TB to cellular proteins and phosphatidylethan...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2493440/ https://ncbi.nlm.nih.gov/pubmed/18547066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800093k |
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