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Covalent Modification of Microsomal Lipids by Thiobenzamide Metabolites in Vivo
Thiobenzamide (TB) is hepatotoxic in rats causing centrolobular necrosis, steatosis, cholestasis and hyperbilirubinemia. It serves as a model compound for a number of thiocarbonyl compounds that undergo oxidative bioactivation to chemically reactive metabolites. The hepatotoxicity of TB is strongly...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527973/ https://ncbi.nlm.nih.gov/pubmed/17381136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx600362h |
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