Covalent Modification of Lipids and Proteins in Rat Hepatocytes, and In Vitro, by Thioacetamide Metabolites

Thioacetamide (TA) is a well-known hepatotoxin in rats. Acute doses cause centrilobular necrosis and hyperbilirubinemia while chronic administration leads to biliary hyperplasia and cholangiocarcinoma. Its acute toxicity requires its oxidation to a stable S-oxide (TASO) that is oxidized further to a...

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Main Authors: Sarma, Diganta, Hajovsky, Heather, Koen, Yakov M., Galeva, Nadezhda A., Williams, Todd D., Staudinger, Jeffrey L., Hanzlik, Robert P.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444623/
https://ncbi.nlm.nih.gov/pubmed/22667464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx3001658
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