Orexin Gene Therapy Restores the Timing and Maintenance of Wakefulness in Narcoleptic Mice

STUDY OBJECTIVES: Narcolepsy is caused by selective loss of the orexin/hypocretin-producing neurons of the hypothalamus. For patients with narcolepsy, chronic sleepiness is often the most disabling symptom, but current therapies rarely normalize alertness and do not address the underlying orexin def...

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Detaylı Bibliyografya
Asıl Yazarlar: Kantor, Sandor, Mochizuki, Takatoshi, Lops, Stefan N., Ko, Brian, Clain, Elizabeth, Clark, Erika, Yamamoto, Mihoko, Scammell, Thomas E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Associated Professional Sleep Societies, LLC 2013
Konular:
Orexin Gene Transfer Restores Wakefulness in Narcoleptic Mice
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700709/
https://ncbi.nlm.nih.gov/pubmed/23904672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.2870
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