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Orexin Gene Therapy Restores the Timing and Maintenance of Wakefulness in Narcoleptic Mice

STUDY OBJECTIVES: Narcolepsy is caused by selective loss of the orexin/hypocretin-producing neurons of the hypothalamus. For patients with narcolepsy, chronic sleepiness is often the most disabling symptom, but current therapies rarely normalize alertness and do not address the underlying orexin def...

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Main Authors: Kantor, Sandor, Mochizuki, Takatoshi, Lops, Stefan N., Ko, Brian, Clain, Elizabeth, Clark, Erika, Yamamoto, Mihoko, Scammell, Thomas E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Associated Professional Sleep Societies, LLC 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700709/
https://ncbi.nlm.nih.gov/pubmed/23904672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.2870
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