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Effects of Paraxanthine and Caffeine on Sleep, Locomotor Activity, and Body Temperature in Orexin/Ataxin-3 Transgenic Narcoleptic Mice

STUDY OBJECTIVE: Caffeine, an adenosine A1 and A2a receptor antagonist, is a widely consumed stimulant and also used for the treatment of hypersomnia; however, the wake-promoting potency of caffeine is often not strong enough, and high doses may induce side effects. Caffeine is metabolized to paraxa...

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Autors principals: Okuro, Masashi, Fujiki, Nobuhiro, Kotorii, Nozomu, Ishimaru, Yuji, Sokoloff, Pierre, Nishino, Seiji
Format: Artigo
Idioma:Inglês
Publicat: Associated Professional Sleep Societies, LLC 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894435/
https://ncbi.nlm.nih.gov/pubmed/20614853
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