Orexin Gene Therapy Restores the Timing and Maintenance of Wakefulness in Narcoleptic Mice

STUDY OBJECTIVES: Narcolepsy is caused by selective loss of the orexin/hypocretin-producing neurons of the hypothalamus. For patients with narcolepsy, chronic sleepiness is often the most disabling symptom, but current therapies rarely normalize alertness and do not address the underlying orexin def...

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Autores principales: Kantor, Sandor, Mochizuki, Takatoshi, Lops, Stefan N., Ko, Brian, Clain, Elizabeth, Clark, Erika, Yamamoto, Mihoko, Scammell, Thomas E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Associated Professional Sleep Societies, LLC 2013
Materias:
Orexin Gene Transfer Restores Wakefulness in Narcoleptic Mice
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700709/
https://ncbi.nlm.nih.gov/pubmed/23904672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.2870
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