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Orexin Gene Therapy Restores the Timing and Maintenance of Wakefulness in Narcoleptic Mice

STUDY OBJECTIVES: Narcolepsy is caused by selective loss of the orexin/hypocretin-producing neurons of the hypothalamus. For patients with narcolepsy, chronic sleepiness is often the most disabling symptom, but current therapies rarely normalize alertness and do not address the underlying orexin def...

詳細記述

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書誌詳細
主要な著者: Kantor, Sandor, Mochizuki, Takatoshi, Lops, Stefan N., Ko, Brian, Clain, Elizabeth, Clark, Erika, Yamamoto, Mihoko, Scammell, Thomas E.
フォーマット: Artigo
言語:Inglês
出版事項: Associated Professional Sleep Societies, LLC 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700709/
https://ncbi.nlm.nih.gov/pubmed/23904672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.2870
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