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Orexin Gene Therapy Restores the Timing and Maintenance of Wakefulness in Narcoleptic Mice
STUDY OBJECTIVES: Narcolepsy is caused by selective loss of the orexin/hypocretin-producing neurons of the hypothalamus. For patients with narcolepsy, chronic sleepiness is often the most disabling symptom, but current therapies rarely normalize alertness and do not address the underlying orexin def...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Associated Professional Sleep Societies, LLC
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3700709/ https://ncbi.nlm.nih.gov/pubmed/23904672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.2870 |
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