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Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice
Narcolepsy is caused by a loss of orexin/hypocretin signaling, resulting in chronic sleepiness, fragmented non-rapid eye movement sleep, and cataplexy. To identify the neuronal circuits underlying narcolepsy, we produced a mouse model in which a loxP-flanked gene cassette disrupts production of the...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060231/ https://ncbi.nlm.nih.gov/pubmed/21368172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012456108 |
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