Orexin Gene Therapy Restores the Timing and Maintenance of Wakefulness in Narcoleptic Mice

STUDY OBJECTIVES: Narcolepsy is caused by selective loss of the orexin/hypocretin-producing neurons of the hypothalamus. For patients with narcolepsy, chronic sleepiness is often the most disabling symptom, but current therapies rarely normalize alertness and do not address the underlying orexin def...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kantor, Sandor, Mochizuki, Takatoshi, Lops, Stefan N., Ko, Brian, Clain, Elizabeth, Clark, Erika, Yamamoto, Mihoko, Scammell, Thomas E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Associated Professional Sleep Societies, LLC 2013
Pynciau:
Orexin Gene Transfer Restores Wakefulness in Narcoleptic Mice
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700709/
https://ncbi.nlm.nih.gov/pubmed/23904672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.2870
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