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Abnormal Sleep/Wake Dynamics in Orexin Knockout Mice

STUDY OBJECTIVES: Narcolepsy with cataplexy is caused by a loss of orexin (hypocretin) signaling, but the physiologic mechanisms that result in poor maintenance of wakefulness and fragmented sleep remain unknown. Conventional scoring of sleep cannot reveal much about the process of transitioning bet...

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Main Authors: Diniz Behn, Cecilia G., Klerman, Elizabeth B., Mochizuki, Takatoshi, Lin, Shih-Chieh, Scammell, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado: Associated Professional Sleep Societies, LLC 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831423/
https://ncbi.nlm.nih.gov/pubmed/20337187
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