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High throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probe
Testing small molecules for their ability to modify cysteine residues of proteins in the early stages of drug discovery is expected to accelerate our ability to develop more selective drugs with lesser side effects. In addition, this approach also enables the rapid evaluation of the mode of binding...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3692575/ https://ncbi.nlm.nih.gov/pubmed/23446699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057113476090 |
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