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High throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probe

Testing small molecules for their ability to modify cysteine residues of proteins in the early stages of drug discovery is expected to accelerate our ability to develop more selective drugs with lesser side effects. In addition, this approach also enables the rapid evaluation of the mode of binding...

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Detalhes bibliográficos
Main Authors: McCallum, Megan M., Nandhikonda, Premchendar, Temmer, Jonathan J., Eyermann, Charles, Simeonov, Anton, Jadhav, Ajit, Yasgar, Adam, Maloney, David, Arnold, Leggy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3692575/
https://ncbi.nlm.nih.gov/pubmed/23446699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057113476090
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