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Synthesis and small-animal positron emission tomography evaluation of [(11)C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier
With the aim to develop a positron emission tomography (PET) tracer to assess the distribution of P-glycoprotein (P-gp) at the blood-brain barrier (BBB) in vivo, the potent third-generation P-gp inhibitor elacridar (1) was labeled with (11)C by reaction of O-desmethyl 1 with [(11)C]-methyl triflate....
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690441/ https://ncbi.nlm.nih.gov/pubmed/19711894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900940f |
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