Synthesis and small-animal positron emission tomography evaluation of [(11)C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier

With the aim to develop a positron emission tomography (PET) tracer to assess the distribution of P-glycoprotein (P-gp) at the blood-brain barrier (BBB) in vivo, the potent third-generation P-gp inhibitor elacridar (1) was labeled with (11)C by reaction of O-desmethyl 1 with [(11)C]-methyl triflate....

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Hauptverfasser: Dörner, Bernd, Kuntner, Claudia, Bankstahl, Jens P., Bankstahl, Marion, Stanek, Johann, Wanek, Thomas, Stundner, Gloria, Mairinger, Severin, Löscher, Wolfgang, Müller, Markus, Langer, Oliver, Erker, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690441/
https://ncbi.nlm.nih.gov/pubmed/19711894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900940f
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