Distinct Role of Pyk2 in Mediating Thromboxane Generation Downstream of Both G(12/13) and Integrin αIIbβ3 in Platelets

Proline-rich tyrosine kinase 2 (Pyk2) is activated by various agonists in platelets. We evaluated the signaling mechanism and the functional role of Pyk2 in platelets by using pharmacological inhibitors and Pyk2-deficient platelets. We found that platelet aggregation and secretion in response to 2-m...

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Autores principales: Kim, Soochong, Cipolla, Lina, Guidetti, Gianni, Okigaki, Mitsuhiko, Jin, Jianguo, Torti, Mauro, Kunapuli, Satya P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689962/
https://ncbi.nlm.nih.gov/pubmed/23640884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.461087
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