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Distinct Role of Pyk2 in Mediating Thromboxane Generation Downstream of Both G(12/13) and Integrin αIIbβ3 in Platelets
Proline-rich tyrosine kinase 2 (Pyk2) is activated by various agonists in platelets. We evaluated the signaling mechanism and the functional role of Pyk2 in platelets by using pharmacological inhibitors and Pyk2-deficient platelets. We found that platelet aggregation and secretion in response to 2-m...
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| Glavni autori: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3689962/ https://ncbi.nlm.nih.gov/pubmed/23640884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.461087 |
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