G(12/13) Signaling Pathways Substitute for Integrin αIIbβ3-Signaling for Thromboxane Generation in Platelets

BACKGROUND: We have previously shown that ADP-induced TXA(2) generation requires signaling from αIIbβ3 integrin in platelets. Here we observed that, unlike ADP, protease-activated receptor (PAR)-mediated TXA(2) generation occurs independently of αIIbβ3. PAR agonists, but not ADP, activate G(12/13) s...

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Detalhes bibliográficos
Main Authors: Bhavaraju, Kamala, Lakhani, Parth R., Dorsam, Robert T., Jin, Jianguo, Hitchcock, Ian S., Sanjay, Archana, Kunapuli, Satya P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037367/
https://ncbi.nlm.nih.gov/pubmed/21347357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016586
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