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Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels
[Image: see text] The molecular chaperone, heat shock protein 70 (Hsp70), is an emerging drug target for treating neurodegenerative tauopathies. We recently found that one promising Hsp70 inhibitor, MKT-077, reduces tau levels in cellular models. However, MKT-077 does not penetrate the blood-brain b...
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| Główni autorzy: | , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American
Chemical Society
2013
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3689201/ https://ncbi.nlm.nih.gov/pubmed/23472668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300210g |
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