Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels

[Image: see text] The molecular chaperone, heat shock protein 70 (Hsp70), is an emerging drug target for treating neurodegenerative tauopathies. We recently found that one promising Hsp70 inhibitor, MKT-077, reduces tau levels in cellular models. However, MKT-077 does not penetrate the blood-brain b...

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Hlavní autoři: Miyata, Yoshinari, Li, Xiaokai, Lee, Hsiu-Fang, Jinwal, Umesh K., Srinivasan, Sharan R., Seguin, Sandlin P., Young, Zapporah T., Brodsky, Jeffrey L., Dickey, Chad A., Sun, Duxin, Gestwicki, Jason E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2013
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689201/
https://ncbi.nlm.nih.gov/pubmed/23472668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300210g
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