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Spontaneous splicing mutations at the dihydrofolate reductase locus in Chinese hamster ovary cells.

We isolated and characterized three spontaneous mutants of Chinese hamster ovary cells that were deficient in dihydrofolate reductase activity. All three mutants contained no detectable enzyme activity and produced dihydrofolate reductase mRNA species that were shorter than those of the wild type by...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Biol
Autori principali: Mitchell, P J, Urlaub, G, Chasin, L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 1986
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC367730/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3023911/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.6.6.1926-1935.1986
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