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S phase-specific synthesis of dihydrofolate reductase in Chinese hamster ovary cells.

We investigated the cell cycle modulation of dihydrofolate reductase (DHFR; tetrahydrofolate dehydrogenase, 7,8-dihydroxyfolate:NADP+ oxidoreductase, EC 1.5.1.3) levels in methotrexate-resistant Chinese hamster ovary cells synchronized by mitotic selection. DNA content and DHFR concentration were an...

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Detalhes bibliográficos
Main Authors: Mariani, B D, Slate, D L, Schimke, R T
Formato: Artigo
Idioma:Inglês
Publicado em: 1981
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC320316/
https://ncbi.nlm.nih.gov/pubmed/6946445
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