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Binding of Mn-deoxyribonucleoside triphosphates to the active site of the DNA polymerase of bacteriophage T7

Divalent metal ions are crucial as cofactors for a variety of intracellular enzymatic activities. Mg(2+), as an example, mediates binding of deoxyribonucleoside 5′-triphosphates followed by their hydrolysis in the active site of DNA polymerase. It is difficult to study the binding of Mg(2+) to an ac...

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Hlavní autoři: Akabayov, Barak, Richardson, Charles C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676745/
https://ncbi.nlm.nih.gov/pubmed/23761703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1154/1.3583156
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