Conformational dynamics of bacteriophage T7 DNA polymerase and its processivity factor, Escherichia coli thioredoxin

Gene 5 of bacteriophage T7 encodes a DNA polymerase (gp5) responsible for the replication of the phage DNA. Gp5 polymerizes nucleotides with low processivity, dissociating after the incorporation of 1 to 50 nucleotides. Thioredoxin (trx) of Escherichia coli binds tightly (Kd = 5 nM) to a unique segm...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Akabayov, Barak, Akabayov, Sabine R., Lee, Seung-Joo, Tabor, Stanley, Kulczyk, Arkadiusz W., Richardson, Charles C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2010
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930546/
https://ncbi.nlm.nih.gov/pubmed/20696935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010141107
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