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An Interaction between DNA Polymerase and Helicase Is Essential for the High Processivity of the Bacteriophage T7 Replisome

Synthesis of the leading DNA strand requires the coordinated activity of DNA polymerase and DNA helicase, whereas synthesis of the lagging strand involves interactions of these proteins with DNA primase. We present the first structural model of a bacteriophage T7 DNA helicase-DNA polymerase complex...

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Detalhes bibliográficos
Main Authors: Kulczyk, Arkadiusz W., Akabayov, Barak, Lee, Seung-Joo, Bostina, Mihnea, Berkowitz, Steven A., Richardson, Charles C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493946/
https://ncbi.nlm.nih.gov/pubmed/22977246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410647
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