Genetic and Phenotypic Characterization of Manufacturing Seeds for a Tetravalent Dengue Vaccine (DENVax)

BACKGROUND: We have developed a manufacturing strategy that can improve the safety and genetic stability of recombinant live-attenuated chimeric dengue vaccine (DENVax) viruses. These viruses, containing the pre-membrane (prM) and envelope (E) genes of dengue serotypes 1–4 in the replicative backgro...

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Detalles Bibliográficos
Autores principales: Huang, Claire Y.-H., Kinney, Richard M., Livengood, Jill A., Bolling, Bethany, Arguello, John J., Luy, Betty E., Silengo, Shawn J., Boroughs, Karen L., Stovall, Janae L., Kalanidhi, Akundi P., Brault, Aaron C., Osorio, Jorge E., Stinchcomb, Dan T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667780/
https://ncbi.nlm.nih.gov/pubmed/23738026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002243
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