Genetic and Phenotypic Characterization of Manufacturing Seeds for a Tetravalent Dengue Vaccine (DENVax)

BACKGROUND: We have developed a manufacturing strategy that can improve the safety and genetic stability of recombinant live-attenuated chimeric dengue vaccine (DENVax) viruses. These viruses, containing the pre-membrane (prM) and envelope (E) genes of dengue serotypes 1–4 in the replicative backgro...

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Detalhes bibliográficos
Main Authors: Huang, Claire Y.-H., Kinney, Richard M., Livengood, Jill A., Bolling, Bethany, Arguello, John J., Luy, Betty E., Silengo, Shawn J., Boroughs, Karen L., Stovall, Janae L., Kalanidhi, Akundi P., Brault, Aaron C., Osorio, Jorge E., Stinchcomb, Dan T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667780/
https://ncbi.nlm.nih.gov/pubmed/23738026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002243
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