Safety and immunogenicity of a recombinant live attenuated tetravalent dengue vaccine (DENVax) in flavivirus-naive healthy adults in Colombia: a randomised, placebo-controlled, phase 1 study

BACKGROUND: Dengue virus is the most serious mosquito-borne viral threat to public health and no vaccines or antiviral therapies are approved for dengue fever. The tetravalent DENVax vaccine contains a molecularly characterised live attenuated dengue serotype-2 virus (DENVax-2) and three recombinant...

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Vydáno v:Lancet Infect Dis
Hlavní autoři: Osorio, Jorge E, Velez, Ivan D, Thomson, Cynthia, Lopez, Liliana, Jimenez, Alejandra, Haller, Aurelia A, Silengo, Shawn, Scott, Jaclyn, Boroughs, Karen L, Stovall, Janae L, Luy, Betty E, Arguello, John, Beatty, Mark E, Santangelo, Joseph, Gordon, Gilad S, Huang, Claire Y-H, Stinchcomb, Dan T
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648257/
https://ncbi.nlm.nih.gov/pubmed/25087476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(14)70811-4
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