Safety and Immunogenicity of a Live Attenuated Tetravalent Dengue Vaccine Candidate in Flavivirus-Naive Adults: A Randomized, Double-Blinded Phase 1 Clinical Trial

Background. Dengue viruses (DENVs) infect >300 million people annually, causing 96 million cases of dengue disease and 22 000 deaths [1]. A safe vaccine that protects against DENV disease is a global health priority [2]. Methods. We enrolled 72 flavivirus-naive healthy adults in a phase 1 double-...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: George, Sarah L., Wong, Mimi A., Dube, Tina J. T., Boroughs, Karen L., Stovall, Janae L., Luy, Betty E., Haller, Aurelia A., Osorio, Jorge E., Eggemeyer, Linda M., Irby-Moore, Sharon, Frey, Sharon E., Huang, Claire Y.-H., Stinchcomb, Dan T.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559193/
https://ncbi.nlm.nih.gov/pubmed/25791116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv179
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