A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands

Notch signaling affects many developmental and cellular processes and has been implicated in congenital disorders, stroke, and numerous cancers. The Notch receptor binds its ligands Delta and Serrate and is able to discriminate between them in different contexts. However, the specific domains in Not...

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Bibliografiske detaljer
Main Authors: Yamamoto, Shinya, Charng, Wu-Lin, Rana, Nadia A., Kakuda, Shinako, Jaiswal, Manish, Bayat, Vafa, Xiong, Bo, Zhang, Ke, Sandoval, Hector, David, Gabriela, Wang, Hao, Haltiwanger, Robert S., Bellen, Hugo J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663443/
https://ncbi.nlm.nih.gov/pubmed/23197537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1228745
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