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Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor
We have mapped a Jagged/Serrate-binding site to specific residues within the 12th EGF domain of human and Drosophila Notch. Two critical residues, involved in a hydrophobic interaction, provide a ligand-binding platform and are adjacent to a Fringe-sensitive residue that modulates Notch activity. Ou...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3591638/ https://ncbi.nlm.nih.gov/pubmed/23339193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.428854 |
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